Protein Details: Sodium channel protein 1 brain

Protein ID

ICDB_Pro_0765

Protein Name

Sodium channel protein 1 brain

Gene Name

Organism

Heterololigo bleekeri (Spear squid) (Loligo bleekeri)

Length

1522 amino acids

AlphaFoldDB

AF-Q05973-F1-model_v4.pdb

Function

Mediates the voltage-dependent sodium ion permeability of excitable membranes. Assuming opened or closed conformations in response to the voltage difference across the membrane; the protein forms a sodium-selective channel through which Na(+) ions may pass in accordance with their electrochemical gradient.

Sequence

MDEKYTAKNRDKTFVVIEKRFKKNIIHRFSAKRSLFLFTPRNPIRRLAVCIATNVCFDYFLMFTIMINCVFLAMPDISEFAEYIFLGIYTMEMAIKLVAGGFFIDKYTYLRDAWNCLDFTVIMISYITLLLQTINDKVISDITGLRTFRVLRALRTLSIIPGLKTMVNALLRALRMLISVLILILFCLWIFSQAGVQLFGGALRHKCVLQIHGSPAFGKTYDEFYAEHIENSDNWLAKGNGEYVLCGNATGAGPCPTNYTCLPDIGENPNYGYTNFDSIGWSMLISFQLLTQDYWEDVYNKVIRAHSPWTVIYFIVINFFGSLYLMNLMLAVVATAYELEVKNTGKKLQQTAATAREQSLKEQERRNTLTVSEADSHVDDRNCTCCEQCCGCCYNPWLRVQSFAHCIITDSFTEVFIIFIIVLNTVFLAMEHHGMSMELKNVLKVANYVFTTVFVLEAILKLLAFNKQYFKSGWNICDLVVVVASLIDLGVEGLKGVSVFRSFRLLRVFHLAQSWTTMRLLLCIILNTLGSLGYLTIILIIVIYIFAVTGLQLFHTEYTPDKFRGEPVPRWNFNDFLHSFMMVFRILCGEWIEPMYDCMRACNGLCFLIFIPVTVFGKTLFFLFIGLVLGAFGSDTVEQEVEVSSFALPGPESKPCSVRERGISATDDNVKDDGQDEVQQNSEETKIDLRNNDKQSKDGMILENNCNNDSLASLGSLGSIPDIMDGSSVEDDISSCQQKDIQPCLPLFISSRFKCLREFDDTSHGKKWNNFRRQLMMVCENKYFETGVLVIIFASSILLAFEDIYLNEKPRLKLAIFYLDITFCLLFFLEMVLKLVALGFVHYYTHFWTILDFTIVIITVISLAASGLGMEQITAFRSLRTLRALRPLRAVSRWQGMKIIVNALMLSIPSIFNVLLVCVVFWLIFAIMGVQLFAGKFYKCVNETNMRIPPTEVANKIECYNKNYTWVNSNVNFDNVGGAFLALFQVATFEGWMEIMADAVDVTEVDEQPKFEATVYYYFYFVLFIIFGSFFVLNLVIGVIIDKFSFLKKKYDGTYLDMFLTPTQQNYYNTLKKLGTKKPQKTVKRPKNKCQAVVYDLVMSNQFEIFITTIIITNMIFMAFEHYNQSEVVTEVLATANIAFTILYAVEAIIKIIGLRIHYLRNLWNVFDFLVVTLSVMDAFLNDIFGDGIFMNPSLLRVARMFRIGRIIRLIKWAKGMRKLLFALVISLPALFNIGALLMLVMFIYTIIGMSSFGQIKLSGALNDQVNFQTFGKTFLLLVRLATSAGWNDILGPLLIQPPNCDPNYITTSTGEKIKVVNGDCGMPWLAISYMVSYIIIVFMIVFNMYIAVILENFNQAHAQEEVGITEDDLDMFYGVWEQYDPLATQFIKHEQLSDFIQDLDPPLKVKKPNNVAIATFDLPIVKGGHIHCLDILLALVKFALGGNLEETEAFKRVRTQMEARFDEIFPTREKSEIRTSTLQMRREEMAARTLQRAWKRRKIMRSFPSPEMIRYFIISAPETAV

PDB Structures

Ligand Binding

1. DICL_CP

2. DICL_Pep

Binding Site

Disease

Location

brain

DOI ID

10.1016/s0006-291x(05)80775-2